Brain Res Bull. 2003 Aug 30;61(4):365-374. Links


Neurodegeneration in amyotrophic lateral sclerosis: the role of oxidative
stress and altered homeostasis of metals.

Carri; MT, Ferri A, Cozzolino M, Calabrese L, Rotilio G.

Dipartimento di Biologia, Universita di Roma "Tor Vergata", Via della Ricerca
Scientifica, 00133, Rome, Italy

Amyotrophic lateral sclerosis is one of the most common neurodegenerative
disorders, with an incidence of about 1/100,000. One of the typical features of
this progressive, lethal disease, occurring both sporadically and as a familial
disorder, is degeneration of cortical and spinal motor neurones. Present
evidence indicates that loss of neurones in patients results from a complex
interplay among oxidative injury, excitotoxic stimulation, dysfunction of
critical proteins and genetic factors. This review focuses on existing evidence
that oxidative stress is a major culprit in the pathogenesis of amyotrophic
lateral sclerosis. An increase in reactive oxygen species and in products of
oxidation has been observed both in post-mortem samples and in experimental
models for ALS. This increase may be consequent to altered metabolism of copper
and iron ions, that share the property to undergo redox cycling and generate
reactive oxygen species. Metal-mediated oxidative stress would lead to several
intracellular alterations and contribute to the induction of cell death
pathways.

PMID: 12909279 [PubMed - as supplied by publisher]

--------------------------------------------------------------------------
------
Who loves ya.
Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking

give it up. You tried this last week. You are worse than my ADD kids I teach


"doe" <ironjustice@aol.comdoe> wrote in message
news:20030820171143.29729.00000228@mb-m24.aol.com...
> Brain Res Bull. 2003 Aug 30;61(4):365-374. Links
>
>
> Neurodegeneration in amyotrophic lateral sclerosis: the role of oxidative
> stress and altered homeostasis of metals.
>
> Carri; MT, Ferri A, Cozzolino M, Calabrese L, Rotilio G.
>
> Dipartimento di Biologia, Universita di Roma "Tor Vergata", Via della
Ricerca
> Scientifica, 00133, Rome, Italy
>
> Amyotrophic lateral sclerosis is one of the most common neurodegenerative
> disorders, with an incidence of about 1/100,000. One of the typical
features of
> this progressive, lethal disease, occurring both sporadically and as a
familial
> disorder, is degeneration of cortical and spinal motor neurones. Present
> evidence indicates that loss of neurones in patients results from a
complex
> interplay among oxidative injury, excitotoxic stimulation, dysfunction of
> critical proteins and genetic factors. This review focuses on existing
evidence
> that oxidative stress is a major culprit in the pathogenesis of
amyotrophic
> lateral sclerosis. An increase in reactive oxygen species and in products
of
> oxidation has been observed both in post-mortem samples and in
experimental
> models for ALS. This increase may be consequent to altered metabolism of
copper
> and iron ions, that share the property to undergo redox cycling and
generate
> reactive oxygen species. Metal-mediated oxidative stress would lead to
several
> intracellular alterations and contribute to the induction of cell death
> pathways.
>
> PMID: 12909279 [PubMed - as supplied by publisher]
>
> --------------------------------------------------------------------------
> ------
> Who loves ya.
> Tom
> Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
> Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
> DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
>
>
>

kill file this people!!!,, or read one of my funny replies to dork, your
choice,, this reply is not funny today.

a friends of mines mother died of ALS,recently,, one month after being dxed
with it,, they had thought she had ms, but this disease took her fast,,

i am sure she would have been cured if she sliced her wrists and did some
blood letting!!!! doe you are a shithead!!!

bobD




"doe" <ironjustice@aol.comdoe> wrote in message
news:20030820171143.29729.00000228@mb-m24.aol.com...
> Brain Res Bull. 2003 Aug 30;61(4):365-374. Links
>
>
> Neurodegeneration in amyotrophic lateral sclerosis: the role of oxidative
> stress and altered homeostasis of metals.
>
> Carri; MT, Ferri A, Cozzolino M, Calabrese L, Rotilio G.
>
> Dipartimento di Biologia, Universita di Roma "Tor Vergata", Via della
Ricerca
> Scientifica, 00133, Rome, Italy
>
> Amyotrophic lateral sclerosis is one of the most common neurodegenerative
> disorders, with an incidence of about 1/100,000. One of the typical
features of
> this progressive, lethal disease, occurring both sporadically and as a
familial
> disorder, is degeneration of cortical and spinal motor neurones. Present
> evidence indicates that loss of neurones in patients results from a
complex
> interplay among oxidative injury, excitotoxic stimulation, dysfunction of
> critical proteins and genetic factors. This review focuses on existing
evidence
> that oxidative stress is a major culprit in the pathogenesis of
amyotrophic
> lateral sclerosis. An increase in reactive oxygen species and in products
of
> oxidation has been observed both in post-mortem samples and in
experimental
> models for ALS. This increase may be consequent to altered metabolism of
copper
> and iron ions, that share the property to undergo redox cycling and
generate
> reactive oxygen species. Metal-mediated oxidative stress would lead to
several
> intracellular alterations and contribute to the induction of cell death
> pathways.
>
> PMID: 12909279 [PubMed - as supplied by publisher]
>
> --------------------------------------------------------------------------
> ------
> Who loves ya.
> Tom
> Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
> Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
> DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
>
>
>

Bob Davidson wrote:

> kill file this people!!!,, or read one of my funny replies
> to dork, your choice,, this reply is not funny today.
>
> a friends of mines mother died of ALS,recently,, one month
> after being dxed with it,, they had thought she had ms, but
> this disease took her fast,,
>
> i am sure she would have been cured if she sliced her
> wrists and did some blood letting!!!! doe you are a shithead!!!

My mother died of ALS many years ago. When I was first diagnosed
with MS, my worst fear was that I had ALS -- I know what it does to
one.

Imagine my horror when someone posted ALS information in this
newsgroup ... and I, assuming that it was somehow related to MS, saw
it.

Now, my doctor assures me that the only connection between the two
is that there's the same word in the names of both diseases ... but
I worry that at some point, someone will find a link.

Posting this information here was insensitive, at best. And that
last sentence was diplomacy at its best!

Kathie

"KT" <adfasdf@adfa.com> wrote in message news:3F44BC38.A53DB4F0@adfa.com...
> Bob Davidson wrote:
>
> > kill file this people!!!,, or read one of my funny replies
> > to dork, your choice,, this reply is not funny today.
> >
> > a friends of mines mother died of ALS,recently,, one month
> > after being dxed with it,, they had thought she had ms, but
> > this disease took her fast,,
> >
> > i am sure she would have been cured if she sliced her
> > wrists and did some blood letting!!!! doe you are a shithead!!!
>
> My mother died of ALS many years ago. When I was first diagnosed
> with MS, my worst fear was that I had ALS -- I know what it does to
> one.
>
> Imagine my horror when someone posted ALS information in this
> newsgroup ... and I, assuming that it was somehow related to MS, saw
> it.
>
> Now, my doctor assures me that the only connection between the two
> is that there's the same word in the names of both diseases ... but
> I worry that at some point, someone will find a link.
>
> Posting this information here was insensitive, at best. And that
> last sentence was diplomacy at its best!
>
> Kathie

hi kathy,, i hope you are doing ok today,, i knew doe's insensitivity,
would cause other people to be upset,,

when i was in highschool we had a friend who had ALS,, we took him to every
concert we went to, pink floyd skylights at the planetarium lazer shows,,
but i saw first hand how als works,, 15 years before i got MS,
he died at ubc hospital long time ago,,

doe is an idiot,, and does not realize the implications of his actions,, i
feel inside every post he sends there is malice,, he wants to cause pain,,
thats why he is a troll.

bobD

>Subject: Re: ALS / amyotrophic lateral sclerosis
>From: "Bob Davidson" phatbhat@shaw.ca
>Date: 8/21/2003 1:15 PM Mountain Daylight Time
>Message-id: <pT81b.800122$3C2.18105634@news3.calgary.shaw.ca >

>> My mother died of ALS many years ago. When I was first diagnosed
>> with MS, my worst fear was that I had ALS -- I know what it does to
>> one.
>>
>> Imagine my horror when someone posted ALS information in this
>> newsgroup ... and I, assuming that it was somehow related to MS, saw
>> it.
>>
>> Now, my doctor assures me that the only connection between the two
>> is that there's the same word in the names of both diseases ... but
>> I worry that at some point, someone will find a link.
>>
>> Posting this information here was insensitive, at best. And that
>> last sentence was diplomacy at its best!
>>

Well your .. OPINION and your welcome to it ..

Your doctor's opinion and HE is welcome to it ..

You don't think .. have even the SLIGHTEST idea if ALS is linked to MS .. but
your doctor does .. and now you feel bad .. ?

Aw shucks ..

Neuroendocrinol Lett. 1999;20(6):351-364. Related Articles, Links


The role of metals in autoimmunity and the link to neuroendocrinology.

Stejskal J, Stejskal VD.

Health University of Linkoping, Sweden.

Current available literature indicates a risk for metal-induced autoimmunity in
man. Metal pathology may be due to toxic or allergic mechanisms where both may
play a role. The main factors decisive for disease induced by metals are
exposure and genetics which determine the individual detoxifying capacity and
sensitivity to metals. This paper reviews the possible mechanisms which may
play a role in metal-induced autoimmunity with the emphasis on multiple
sclerosis (MS), rheumatoid arthritis (RA) and amyotrophic lateral sclerosis
(ALS). We also discuss the role of inflammation-induced changes in the
hypothalamus-pituitary-adrenal (HPA) axis as a possible explanation of fatigue,
depression and other psychosomatic symptoms observed in these diseases. The
increased knowledge about individual sensitivity based on genotype and
phenotype variability together with the use of biomarkers for the diagnosis of
this individual susceptibility seems to be the key in elucidation of the
operating mechanisms. Since metal-induced sensitization may be induced by
chronic low-dose exposure, the conventional toxicological approach comparing
concentrations of metals in brain autopsies, organ biopsies and body fluids in
patients and controls may not provide answers regarding the metal-pathology
connection. To address this issue, longitudinal studies of metal-sensitive
patients are preferable to the traditional case-control studies.

PMID: 11458198 [PubMed - as supplied by publisher]

--------------------------------------------------------------------------
------

>i
>feel inside every post he sends there is malice,, he wants to cause pain,,
>thats why he is a troll.

Seeing the link between schizophrenia / mental illness .. and MS .. I am not
surprised you feel a little paranoid there .. bob ..

Have a cigarette ..

Who loves ya.
Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking

Bob Davidson wrote:

> hi kathy,, i hope you are doing ok today,, i knew doe's
> insensitivity, would cause other people to be upset,,
>
> when i was in highschool we had a friend who had ALS,, we
> took him to every concert we went to, pink floyd skylights
> at the planetarium lazer shows,, but i saw first hand how
> als works,, 15 years before i got MS, he died at ubc
> hospital long time ago,,
>
> doe is an idiot,, and does not realize the implications of
> his actions,, i feel inside every post he sends there is
> malice,, he wants to cause pain,, thats why he is a troll.

Fortunately, I know enough not to read his posts ... but seeing that
header, of course, I did ... my own fault for thinking there might
be something interesting, important, etc.

And yes, thanks ... I'm fine.

Kathie

Kathie;

> Imagine my horror when someone posted ALS information in this
> newsgroup ... and I, assuming that it was somehow related to MS, saw
> it.
>
> Now, my doctor assures me that the only connection between the two
> is that there's the same word in the names of both diseases ... but
> I worry that at some point, someone will find a link.
>
> Posting this information here was insensitive, at best. And that
> last sentence was diplomacy at its best!

I'm so sorry that you were upset by our resident moron, Tom Hennessey.

He has no real knowledge of any kind. He has been told a hundred
times that's he's not welcome here, he has no business here, no one
wants him here, but he continues to post irrelevant garbage here.

If there is any new knowledge about anything, he won't understand it
anyway.

Killfile him or ignore him; he's worse than useless.

Sylvia

in article 3F44BC38.A53DB4F0@adfa.com, KT at adfasdf@adfa.com wrote on
8/21/03 8:33 AM:

> Imagine my horror when someone posted ALS information in this
> newsgroup

One of the things you quickly learn about disease newsgroups is that they
attract the same kind of nutballs who claim to have invented perpetual
motion machines. Tom ("doe") is one of those. You can ignore everything he
says unless you're in the mood for a laugh.


Keith

http://www.journalscape.com/keithsnyder